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Literature summary for 1.17.4.4 extracted from
- Human herpesvirus 8 viral interleukin-6 interacts with splice variant 2 of vitamin K epoxide reductase complex subunit 1 (2012), J. Virol., 86, 1577-1588.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of the human enzyme with the human herpesvirus 8 viral interleukin-6 in the yeast two-hybrid system using Saccharomyces cerevisiae strain AH109 | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum membrane | splice variant 2 of vitamin K epoxide reductase complex subunit 1 adopts a single-transmembrane topology placing the C tail in the endoplasmic reticulum lumen | Homo sapiens | 5789 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Homo sapiens | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Homo sapiens | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| vitamin K epoxide reductase complex subunit 1 | - |
Homo sapiens |
| VKORC1 | - |
Homo sapiens |
| VKORC1 variant 2 | - |
Homo sapiens |
| VKORC1v2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | human herpesvirus 8 viral interleukin-6 interacts with splice variant 2 of vitamin K epoxide reductase complex subunit 1, VKORC1v2, via the C-terminal residues 31-39 of the enzyme in the endoplasmic reticulum lumen, interaction analysis, VKORC1v2 to intracellular retention of endogenously expressed vIL-6, detailed overview | Homo sapiens |
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