Cloned (Comment) | Organism |
---|---|
expressionof N- and C-terminally GFP-tagged enzyme in HEK293 cells, the N-terminus of VKOR resides in the ER lumen, whereas its C-terminus is in the cytoplasm | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C43A/C51A | site-directed mutagenesis, the mutation has a minor effect on VKOR activity, the mutant of the altered four-transmembrane domain form of VKOR is more active than the wild-type three-transmembrane domain enzyme | Homo sapiens |
C51A | site-directed mutagenesis, the mutation has a minor effect on VKOR activity, the mutant of the altered four-transmembrane domain form of VKOR is more active than the wild-type three-transmembrane domain enzyme | Homo sapiens |
G6R | site-directed mutagenesis, the mutant shows altered membrane topology compared to the wild-type enzyme | Homo sapiens |
G9R | site-directed mutagenesis, the mutant shows altered membrane topology compared to the wild-type enzyme | Homo sapiens |
K30L | site-directed mutagenesis, the mutation close to the transmembrane domain 1 leads to altered membrane topology compared to the wild-type enzyme | Homo sapiens |
R33G | site-directed mutagenesis, the mutation close to the transmembrane domain 1 leads to altered membrane topology compared to the wild-type enzyme | Homo sapiens |
R35G | site-directed mutagenesis, the mutation close to the transmembrane domain 1 leads to altered membrane topology compared to the wild-type enzyme | Homo sapiens |
R37G | site-directed mutagenesis, the mutation close to the transmembrane domain 1 leads to altered membrane topology compared to the wild-type enzyme | Homo sapiens |
S7R | site-directed mutagenesis, the mutant shows altered membrane topology compared to the wild-type enzyme | Homo sapiens |
Y139F | the mutant is warfarin insensitive and shows altered membrane topology compared to the wild-type enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | the N-terminus of VKOR resides in the endoplasmic reticulum lumen, whereas its C-terminus is in the cytoplasm, three- and four-transmembrane domain topology models, overview | Homo sapiens | 5789 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Homo sapiens | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | in vitro glycosylation mapping | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Homo sapiens | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
vitamin K epoxide reductase | - |
Homo sapiens |
VKOR | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | membrane topology models for human VKOR, overview | Homo sapiens |
physiological function | vitamin K epoxide reductase is essential for the production of reduced vitamin K that is required for modification of vitamin K-dependent proteins | Homo sapiens |