Inhibitors | Comment | Organism | Structure |
---|---|---|---|
warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7- and 10-hydroxylated warfarin | Anas platyrhynchos | |
warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, and 8-hydroxylated warfarin | Bubo scandiacus | |
warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, and 8-hydroxylated warfarin | Bubo virginianus | |
warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, 8- and 10-hydroxylated warfarin | Gallus gallus | |
warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, 8- and 10-hydroxylated warfarin | Rattus norvegicus | |
warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, and 8-hydroxylated warfarin | Struthio camelus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1658 | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone | pH 7.4, 37°C | Gallus gallus | |
0.1761 | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone | pH 7.4, 37°C | Rattus norvegicus | |
0.1875 | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone | pH 7.4, 37°C | Struthio camelus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Gallus gallus | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Anas platyrhynchos | - |
- |
microsome | - |
Struthio camelus | - |
- |
microsome | - |
Bubo scandiacus | - |
- |
microsome | - |
Bubo virginianus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Gallus gallus | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Rattus norvegicus | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Anas platyrhynchos | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Struthio camelus | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Bubo scandiacus | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Bubo virginianus | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Gallus gallus | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Rattus norvegicus | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Anas platyrhynchos | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Struthio camelus | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Bubo scandiacus | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Bubo virginianus | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Anas platyrhynchos | - |
- |
- |
Bubo scandiacus | - |
- |
- |
Bubo virginianus | - |
- |
- |
Gallus gallus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Struthio camelus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partially by microsome preparation by ultracentrifugation | Rattus norvegicus |
partially by microsome preparation by ultracentrifugation | Anas platyrhynchos |
partially by microsome preparation by ultracentrifugation | Struthio camelus |
partially by microsome preparation by ultracentrifugation | Bubo scandiacus |
partially by microsome preparation by ultracentrifugation | Bubo virginianus |
partially, microsome preparation by ultracentrifugation | Gallus gallus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Gallus gallus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Anas platyrhynchos | - |
liver | - |
Struthio camelus | - |
liver | - |
Bubo scandiacus | - |
liver | - |
Bubo virginianus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Gallus gallus | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Rattus norvegicus | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Anas platyrhynchos | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Struthio camelus | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Bubo scandiacus | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Bubo virginianus | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Gallus gallus | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Rattus norvegicus | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Anas platyrhynchos | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Struthio camelus | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Bubo scandiacus | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Bubo virginianus | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r |
Synonyms | Comment | Organism |
---|---|---|
vitamin K 2,3-epoxide reductase | - |
Gallus gallus |
vitamin K 2,3-epoxide reductase | - |
Rattus norvegicus |
vitamin K 2,3-epoxide reductase | - |
Anas platyrhynchos |
vitamin K 2,3-epoxide reductase | - |
Struthio camelus |
vitamin K 2,3-epoxide reductase | - |
Bubo scandiacus |
vitamin K 2,3-epoxide reductase | - |
Bubo virginianus |
VKOR | - |
Gallus gallus |
VKOR | - |
Rattus norvegicus |
VKOR | - |
Anas platyrhynchos |
VKOR | - |
Struthio camelus |
VKOR | - |
Bubo scandiacus |
VKOR | - |
Bubo virginianus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Rattus norvegicus |
37 | - |
- |
Anas platyrhynchos |
38 | - |
- |
Struthio camelus |
41 | - |
- |
Bubo scandiacus |
41 | - |
- |
Bubo virginianus |
42 | - |
- |
Gallus gallus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Gallus gallus |
7.4 | - |
assay at | Rattus norvegicus |
7.4 | - |
assay at | Anas platyrhynchos |
7.4 | - |
assay at | Struthio camelus |
7.4 | - |
assay at | Bubo scandiacus |
7.4 | - |
assay at | Bubo virginianus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00028 | - |
warfarin | pH 7.4, 37°C | Rattus norvegicus | |
0.00064 | - |
warfarin | pH 7.4, 38°C | Struthio camelus | |
0.0113 | - |
warfarin | pH 7.4, 42°C | Gallus gallus |
General Information | Comment | Organism |
---|---|---|
evolution | clear difference in VKOR activity and Ki for warfarin among bird species | Gallus gallus |
evolution | clear difference in VKOR activity and Ki for warfarin among bird species | Anas platyrhynchos |
evolution | clear difference in VKOR activity and Ki for warfarin among bird species | Struthio camelus |
evolution | clear difference in VKOR activity and Ki for warfarin among bird species | Bubo scandiacus |
evolution | clear difference in VKOR activity and Ki for warfarin among bird species | Bubo virginianus |