Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | bacitracin inhibition of reduced RNase triggers VKOR activity, overview | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
gene VKORC1, expression of the c-myc-tagged VKORC1 in HEK-293 cells and in BHK21 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA silencing of VKOR complex subunit PDI | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | - |
Rattus norvegicus | 5789 | - |
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Rattus norvegicus | i.e. vitamin K 2,3-epoxide | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
additional information | Rattus norvegicus | the reduction is linked to dithiol-dependent oxidative folding of proteins in the ER by protein disulfide isomerase, PDI, oxidative folding of reduced RNase triggers the reduction of vitamin K epoxid and the gamma-carboxylation of the synthetic gamma-carboxylase peptide substrate FLEEL, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
gene VKORC1 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | VKORC1has a consensus sequence for glycosylation | Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
native enzyme from liver microsomes by solubilization, pH 11, deoxycholate-Tris base microsome extraction procedure, immunoprecipitation, gel filtration, and protein A and protein G affinity chromatography | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Rattus norvegicus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
additional information | the reduction is linked to dithiol-dependent oxidative folding of proteins in the ER by protein disulfide isomerase, PDI, oxidative folding of reduced RNase triggers the reduction of vitamin K epoxid and the gamma-carboxylation of the synthetic gamma-carboxylase peptide substrate FLEEL, overview | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the VKOR enzyme complex contains protein disulfide reductase, PDI, and VKORC1 as tightly associated subunits, complex organization and structure, overview, VKORC! is a highly hydrophobic protein | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
vitamin K 2,3-epoxide reductase | - |
Rattus norvegicus |
VKOR | - |
Rattus norvegicus |