Literature summary for 1.17.4.4 extracted from

Deerfield, D.I.; Davis, C.H.; Wymore, T.; Stafford, D.W.; Pedersen, L.G.
Quantum chemical study of the mechanism of action of vitamin K epoxide reductase (VKOR) (2006), Int. J. Quantum Chem., 106, 2944-2952.

No PubMed abstract available

Search for more literature for 1.17.4.4

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	detailed thermodynamics, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol	Homo sapiens	i.e. vitamin K 2,3-epoxide, the enzyme initiates the vitamin K catalytic cycle, overview	2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol	i.e. vitamin K	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues	analysis of the reaction mechanism by quantum mechanical methods, modeling, the geometries of proposed model intermediates in the mechanisms are energy optimized	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol	i.e. vitamin K 2,3-epoxide	Homo sapiens	2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol	i.e. vitamin K	?
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol	i.e. vitamin K 2,3-epoxide, the enzyme initiates the vitamin K catalytic cycle, overview	Homo sapiens	2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol	i.e. vitamin K	?

Synonyms

Synonyms	Comment	Organism
vitamin K epoxide reductase	-	Homo sapiens
VKOR	-	Homo sapiens

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Release 2023.1 (January 2023)