Literature summary for 1.17.4.4 extracted from

Rettie, A.E.; Farin, F.M.; Beri, N.G.; Srinouanprachanh, S.L.; Rieder, M.J.; Thijssen, H.H.
A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9 (2006), Br. J. Clin. Pharmacol., 62, 617-620.

Search for more literature for 1.17.4.4

Activating Compound

Activating Compound	Comment	Organism	Structure
warfarin	dependent on	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene VKORC1, genotyping, phenotypes of enzyme single nucleotide polymorphisms naturally occuring in Caucasian population	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C6009T	naturally occuring single nucleotide polymorphism	Homo sapiens
C6484T	naturally occuring single nucleotide polymorphism	Homo sapiens
G2653C	naturally occuring single nucleotide polymorphism	Homo sapiens
G3673A	naturally occuring single nucleotide polymorphism	Homo sapiens
G6853C	naturally occuring single nucleotide polymorphism	Homo sapiens
G9041A	naturally occuring single nucleotide polymorphism	Homo sapiens
T5808G	naturally occuring single nucleotide polymorphism	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme is involved in regulation of response to oral anticoagulants of European-American warfarin patients	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	gene VKORC1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is involved in regulation of response to oral anticoagulants of European-American warfarin patients	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
VKORC1	-	Homo sapiens

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Release 2023.1 (January 2023)