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Literature summary for 1.17.4.4 extracted from

  • Silverman, R.B.; Nandi, D.R.
    Reduced thioredoxin: a possible physiological cofactor for vitamin K epoxide reductase. Further support for an active site disulfide (1988), Biochem. Biophys. Res. Commun., 155, 1248-1254.
    View publication on PubMed
Search for more literature for 1.17.4.4

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol
-
 Rattus norvegicus
dithiothreitol
-
 Bos taurus
GSH activation, 6% as effective as DTT Rattus norvegicus
GSH activation, 6% as effective as DTT Bos taurus
lipoic acid activation, less effective than DTT Rattus norvegicus
lipoic acid activation, less effective than DTT Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
warfarin
-
 Bos taurus
warfarin
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome integral membrane protein Rattus norvegicus
-
-
microsome integral membrane protein Bos taurus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
vitamin K 2,3-epoxide + dithiothreitol Bos taurus
-
 vitamin K + oxidized dithiothreitol
-
 ?
vitamin K 2,3-epoxide + dithiothreitol Rattus norvegicus thioredoxin is the possible physiological electron acceptor vitamin K + oxidized dithiothreitol
-
 ?
vitamin K 2,3-epoxide + dithiothreitol Rattus norvegicus Wistar thioredoxin is the possible physiological electron acceptor vitamin K + oxidized dithiothreitol
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
 Wistar strain
-
Rattus norvegicus Wistar
-
 Wistar strain
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?
vitamin K 2,3-epoxide + dithiothreitol
-
 Bos taurus vitamin K + oxidized dithiothreitol
-
 ?
vitamin K 2,3-epoxide + dithiothreitol thioredoxin is the possible physiological electron acceptor Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?
vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus Wistar vitamin K + oxidized dithiothreitol
-
 ?
vitamin K 2,3-epoxide + dithiothreitol thioredoxin is the possible physiological electron acceptor Rattus norvegicus Wistar vitamin K + oxidized dithiothreitol
-
 ?

Cofactor

Cofactor Comment Organism Structure
reduced thioredoxin likely physiological cofactor, more potent than dithiothreitol Rattus norvegicus
reduced thioredoxin likely physiological cofactor, more potent than dithiothreitol Bos taurus