Inhibitors | Comment | Organism | Structure |
---|---|---|---|
caracemide | - |
Escherichia coli | |
caracemide | - |
Mus musculus | |
caracemide | - |
Tequatrovirus T4 | |
chlorambucil | - |
Escherichia coli | |
chlorambucil | - |
Mus musculus | |
chlorambucil | - |
Tequatrovirus T4 | |
cisplatin | - |
Escherichia coli | |
cisplatin | - |
Mus musculus | |
cisplatin | - |
Tequatrovirus T4 | |
Co2+ | RNR activity chelates with copper leading to inactivation | Escherichia coli | |
Co2+ | RNR activity chelates with copper leading to inactivation | Mus musculus | |
Co2+ | RNR activity chelates with copper leading to inactivation | Tequatrovirus T4 |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | class II enzymes contain cobalamin as cofactor | Mus musculus | |
Co2+ | class II enzymes contain cobalamin as cofactor | Escherichia coli | |
Fe2+ | the class III enzymes contain 4Fe-4S clusters in the small beta-subunit | Escherichia coli | |
Fe2+ | the class III enzymes contain 4Fe-4S clusters in the small beta-subunit | Tequatrovirus T4 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | class II RNRs convert nucleoside triphosphates and nucleoside 5'-diphosphates, see also EC 1.17.4.1, to the correspondent 2'-deoxy products, overview | ? | - |
? | |
additional information | Mus musculus | class II RNRs convert nucleoside triphosphates and nucleoside 5'-diphosphates, see also EC 1.17.4.1, to the correspondent 2'deoxy products, overview | ? | - |
? | |
nucleoside 5'-triphosphate + formate | Escherichia coli | class III RNR | 2'-deoxynucleoside 5'-triphosphate + H2O | - |
? | |
nucleoside 5'-triphosphate + formate | Tequatrovirus T4 | class III RNR | 2'-deoxynucleoside 5'-triphosphate + H2O | - |
? | |
nucleoside 5'-triphosphate + thioredoxin | Mus musculus | class II RNRs | 2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O | - |
? | |
nucleoside 5'-triphosphate + thioredoxin | Escherichia coli | class II RNRs | 2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Mus musculus | - |
- |
- |
Tequatrovirus T4 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | class II RNRs convert nucleoside triphosphates and nucleoside 5'-diphosphates, see also EC 1.17.4.1, to the correspondent 2'-deoxy products, overview | Escherichia coli | ? | - |
? | |
additional information | class II RNRs convert nucleoside triphosphates and nucleoside 5'-diphosphates, see also EC 1.17.4.1, to the correspondent 2'deoxy products, overview | Mus musculus | ? | - |
? | |
additional information | the class II RNR also uses nucleoside 5'-diphosphate as substrate | Mus musculus | ? | - |
? | |
additional information | the class II RNR also uses nucleoside 5'-diphosphate as substrate | Escherichia coli | ? | - |
? | |
nucleoside 5'-triphosphate + formate | class III RNR | Escherichia coli | 2'-deoxynucleoside 5'-triphosphate + H2O | - |
? | |
nucleoside 5'-triphosphate + formate | class III RNR | Tequatrovirus T4 | 2'-deoxynucleoside 5'-triphosphate + H2O | - |
? | |
nucleoside 5'-triphosphate + thioredoxin | class II RNRs | Mus musculus | 2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O | - |
? | |
nucleoside 5'-triphosphate + thioredoxin | class II RNRs | Escherichia coli | 2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer or dimer | alpha or alpha2, class II RNRs | Mus musculus |
monomer or dimer | alpha or alpha2, class II RNRs | Escherichia coli |
More | structure comparisons of classI-III RNRs, model for the subunit organization of RNRs, overview | Mus musculus |
More | structure comparisons of classI-III RNRs, model for the subunit organization of RNRs, overview | Escherichia coli |
More | structure comparisons of classI-III RNRs, model for the subunit organization of RNRs, overview | Tequatrovirus T4 |
tetramer | alpha2beta2, class III RNRs | Escherichia coli |
tetramer | alpha2beta2, class III RNRs | Tequatrovirus T4 |
Synonyms | Comment | Organism |
---|---|---|
class II RNR | cf. EC 1.17.4.1 | Mus musculus |
class II RNR | cf. EC 1.17.4.1 | Escherichia coli |
class III RNR | - |
Escherichia coli |
class III RNR | - |
Tequatrovirus T4 |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5'-deoxyadenosylcobalamin | class II enzymes | Mus musculus | |
5'-deoxyadenosylcobalamin | class II enzymes | Escherichia coli | |
Cobalamin | class II enzymes | Mus musculus | |
Cobalamin | class II enzymes | Escherichia coli | |
additional information | cofactor specificity and binding, role in reaction, overview | Mus musculus | |
additional information | cofactor specificity and binding, role in reaction, overview | Escherichia coli | |
additional information | the class III enzymes contain 4Fe-4S clusters in the small beta-subunit. Cofactor specificity and binding, role in reaction, overview | Escherichia coli | |
additional information | the class III enzymes contain 4Fe-4S clusters in the small beta-subunit. Cofactor specificity and binding, role in reaction, overview | Tequatrovirus T4 | |
S-adenosyl-L-methionine | - |
Escherichia coli | |
S-adenosyl-L-methionine | - |
Tequatrovirus T4 | |
thioredoxin | - |
Escherichia coli | |
thioredoxin | class II enzymes | Mus musculus |
General Information | Comment | Organism |
---|---|---|
additional information | Cys290 in class III from bacteriophage T4 are the conserved cysteine residues that are the sites for generation of the thiyl radical | Tequatrovirus T4 |
additional information | the class II RNR reaction involves deoxyadenosyl or cysteinyl radicals and is independent of oxygen. The thiyl radical in class II RNR is believed to be generated directly at the active site using the cofactor 5'-deoxyadenosylcobalamin | Mus musculus |
additional information | the class II RNR reaction involves deoxyadenosyl or cysteinyl radicals and is independent of oxygen. The thiyl radical in class II RNR is believed to be generated directly at the active site using the cofactor 5'-deoxyadenosylcobalamin | Escherichia coli |
additional information | the class III RNR reaction involves deoxyadenosyl, glycyl, or cysteinyl radicals and requires anaerobic conditions | Escherichia coli |
physiological function | during anaerobic growth, Escherichia coli depends on a class III RNR for the synthesis of deoxyribonucleotides | Escherichia coli |