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Literature summary for 1.17.4.2 extracted from
- Understanding ribonucleotide reductase inactivation by gemcitabine (2007), Chemistry, 13, 8507-8515.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| gemcitabine | i.e. 2',2'-difluoro-2'-deoxycytidine, dFdC, a deoxycytidine analogue, very active drug against solid tumors, the RNR inactivation is reductant-dependent for R1 subunit, but reductant-independent for the R2 subunit, R1 inactivation is the most favorable mechanism responsible for the drug's cytotoxicity, overview, binding and inhibition mechanism including the formation of a Cys225-Cys462 disulfide bridge, detailed overview | Escherichia coli |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | ribonucleotide diphosphate reductase class Ia | Escherichia coli |
| ribonucleotide diphosphate reductase | - |
Escherichia coli |
| RNR | - |
Escherichia coli |
| RNR class Ia | - |
Escherichia coli |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics with gemcitabine | Escherichia coli |
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