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Literature summary for 1.17.4.2 extracted from

  • Liu, X.; Zhou, B.; Xue, L.; Shih, J.; Tye, K.; Qi, C.; Yen, Y.
    The ribonucleotide reductase subunit M2B subcellular localization and functional importance for DNA replication in physiological growth of KB cells (2005), Biochem. Pharmacol., 70, 1288-1297.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm in response to DNA replication, subunit M2B redistributes from the cytoplasm to the nucleus Homo sapiens 5737
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nucleus in response to DNA replication, subunit M2B redistributes from the cytoplasm to the nucleus Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens p53-dependent small enzyme subunit M2B may play an important role for initiating DNA replication in normal growth ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
KB cell oropharyngeal epidermal carcinoma cell line. At G1/S phase transition, level of p53-dependent small enzyme subunit M2B increases to maximum levles, and decreases with DNA synthesis. In response to DNA replication, subunit M2B redistributes from the cytoplasm to the nucleus earlier than small subunit M2 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information p53-dependent small enzyme subunit M2B may play an important role for initiating DNA replication in normal growth Homo sapiens ?
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 ?