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Literature summary for 1.17.4.2 extracted from
- Ribonucleoside triphosphate reductase from Lactobacillus leichmannii: Kinetic evaluation of a series of adenosylcobalamin competitive inhibitors, [omega-(adenosin-5'-O-yl)alkyl]cobalamins, which mimic the post Co-C homolysis intermediate (1999), Bioorg. Chem., 27, 451-462.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 5'-deoxyadenosylcobalamin | - |
Lactobacillus leichmannii |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpressed in Escherichia coli | Lactobacillus leichmannii |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cob(II)alamin | - |
Lactobacillus leichmannii | |
| cyanocobalamin | - |
Lactobacillus leichmannii | |
| [3-(adenosin-5'-O-yl)propyl]cobalamin | - |
Lactobacillus leichmannii | |
| [4-(adenosin-5'-O-yl)butyl]cobalamin | - |
Lactobacillus leichmannii | |
| [5-(adenosin-5'-O-yl)pentyl]cobalamin | - |
Lactobacillus leichmannii | |
| [6-(adenosin-5'-O-yl)hexyl]cobalamin | - |
Lactobacillus leichmannii | |
| [7-(adenosin-5'-O-yl)heptyl]cobalamin | - |
Lactobacillus leichmannii | |
| [omega-(adenosin-5'-O-yl)alkyl]cobalamin | - |
Lactobacillus leichmannii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ribonucleoside triphosphate + reduced thioredoxin + H2O | Lactobacillus leichmannii | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lactobacillus leichmannii | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from overexpressing Escherichia coli cells | Lactobacillus leichmannii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ribonucleoside triphosphate + reduced thioredoxin | - |
Lactobacillus leichmannii | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
| ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Lactobacillus leichmannii | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RTPR | - |
Lactobacillus leichmannii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| coenzyme B12 | adenosylcobalamin | Lactobacillus leichmannii | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0077 | - |
[5-(adenosin-5'-O-yl)pentyl]cobalamin | - |
Lactobacillus leichmannii | |
| 0.0128 | - |
[7-(adenosin-5'-O-yl)heptyl]cobalamin | - |
Lactobacillus leichmannii | |
| 0.0143 | - |
cob(II)alamin | + adenosine | Lactobacillus leichmannii | |
| 0.0189 | - |
[4-(adenosin-5'-O-yl)butyl]cobalamin | - |
Lactobacillus leichmannii | |
| 0.0208 | - |
cob(II)alamin | - |
Lactobacillus leichmannii | |
| 0.0246 | - |
[6-(adenosin-5'-O-yl)hexyl]cobalamin | - |
Lactobacillus leichmannii | |
| 0.0426 | - |
cyanocobalamin | - |
Lactobacillus leichmannii | |
| 0.0558 | - |
[3-(adenosin-5'-O-yl)propyl]cobalamin | - |
Lactobacillus leichmannii | |
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Release 2023.1 (January 2023)
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