Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Deinococcus radiodurans | |
ATP | stimulates CDP reduction | Thermotoga maritima | |
dATP | - |
Thermotoga maritima | |
dATP | - |
Lactobacillus leichmannii | |
dATP | - |
Deinococcus radiodurans |
Cloned (Comment) | Organism |
---|---|
cloned by PCR from peptide sequence information | Deinococcus radiodurans |
cloned by PCR from peptide sequence information, nrdj gene sequenced completely and expressed in Escherichia coli BL21(DE3) | Thermotoga maritima |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dGTP | inhibits CDP reduction | Deinococcus radiodurans | |
dGTP | inhibits CDP reduction | Thermotoga maritima | |
dTTP | inhibits CDP reduction | Deinococcus radiodurans | |
dTTP | - |
Lactobacillus leichmannii | |
dTTP | inhibits CDP reduction | Thermotoga maritima |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Thermotoga maritima | |
Ca2+ | - |
Deinococcus radiodurans | |
Mg2+ | - |
Escherichia coli | |
Mg2+ | - |
Thermotoga maritima | |
Mg2+ | - |
Deinococcus radiodurans |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
90000 | - |
- |
Pyrococcus furiosus |
90000 | - |
gel filtraton | Thermotoga maritima |
107000 | - |
deduced amino acid sequence | Deinococcus radiodurans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ribonucleoside triphosphate + reduced thioredoxin + H2O | Escherichia coli | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Pyrococcus furiosus | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Thermoplasma acidophilum | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Mycobacterium tuberculosis | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Methanocaldococcus jannaschii | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Archaeoglobus fulgidus | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Thermotoga maritima | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Lactobacillus leichmannii | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Chloroflexus aurantiacus | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Deinococcus radiodurans | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Archaeoglobus fulgidus | - |
- |
- |
Chloroflexus aurantiacus | - |
J-10-fl (ATCC 29366) | - |
Deinococcus radiodurans | - |
- |
- |
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 | - |
- |
- |
Escherichia coli | - |
- |
- |
Lactobacillus leichmannii | - |
- |
- |
Methanocaldococcus jannaschii | - |
- |
- |
Mycobacterium tuberculosis | - |
- |
- |
Pyrococcus furiosus | - |
- |
- |
Thermoplasma acidophilum | - |
- |
- |
Thermotoga maritima | - |
- |
- |
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Thermotoga maritima |
- |
Deinococcus radiodurans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP + reduced thioredoxin | - |
Escherichia coli | dCDP + oxidized thioredoxin + H2O | - |
? | |
CDP + reduced thioredoxin | - |
Pyrococcus furiosus | dCDP + oxidized thioredoxin + H2O | - |
? | |
CDP + reduced thioredoxin | - |
Thermotoga maritima | dCDP + oxidized thioredoxin + H2O | - |
? | |
CDP + reduced thioredoxin | - |
Lactobacillus leichmannii | dCDP + oxidized thioredoxin + H2O | - |
? | |
CDP + reduced thioredoxin | - |
Deinococcus radiodurans | dCDP + oxidized thioredoxin + H2O | - |
? | |
CDP + reduced thioredoxin | - |
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 | dCDP + oxidized thioredoxin + H2O | - |
? | |
CDP + reduced thioredoxin | - |
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 | dCDP + oxidized thioredoxin + H2O | - |
? | |
CTP + reduced thioredoxin | - |
Thermotoga maritima | dCTP + oxidized thioredoxin + H2O | - |
? | |
CTP + reduced thioredoxin | - |
Lactobacillus leichmannii | dCTP + oxidized thioredoxin + H2O | - |
? | |
CTP + reduced thioredoxin | - |
Deinococcus radiodurans | dCTP + oxidized thioredoxin + H2O | - |
? | |
CTP + reduced thioredoxin | - |
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 | dCTP + oxidized thioredoxin + H2O | - |
? | |
CTP + reduced thioredoxin | - |
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 | dCTP + oxidized thioredoxin + H2O | - |
? | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Escherichia coli | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Pyrococcus furiosus | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Thermoplasma acidophilum | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Mycobacterium tuberculosis | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Methanocaldococcus jannaschii | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Archaeoglobus fulgidus | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Thermotoga maritima | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Lactobacillus leichmannii | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Chloroflexus aurantiacus | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Deinococcus radiodurans | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin | - |
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Escherichia coli | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Pyrococcus furiosus | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Thermoplasma acidophilum | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Mycobacterium tuberculosis | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Methanocaldococcus jannaschii | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Archaeoglobus fulgidus | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Thermotoga maritima | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Lactobacillus leichmannii | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Chloroflexus aurantiacus | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Deinococcus radiodurans | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
80 | 90 | - |
Thermotoga maritima |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
coenzyme B12 | - |
Thermoplasma acidophilum | |
coenzyme B12 | - |
Mycobacterium tuberculosis | |
coenzyme B12 | adenosylcobalamin | Pyrococcus furiosus | |
coenzyme B12 | adenosylcobalamin | Lactobacillus leichmannii |