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Literature summary for 1.17.4.1 extracted from

  • Mazumder, A.; Tummler, K.; Bathe, M.; Samson, L.D.
    Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage (2013), Mol. Cell. Biol., 33, 635-642.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Expression

Organism Comment Expression
Saccharomyces cerevisiae ribonucleotide reductase subunit mRNA levels are comparably low in both damaged and undamaged G1 cells and highly induced in damaged S/G2 cells. Transcript numbers becomes correlated with both protein levels and localization only upon DNA damage in a cell cycle-dependent manner. The differential ribonucleotide reductase response to DNA damage correlates with variable Mec1 kinase activity in the cell cycle in single cells. The transcription of ribonucleotide reductase genes is noisy and non-Poissonian in nature additional information

General Information

General Information Comment Organism
physiological function the ribonucleotide reductase response to DNA damage does not operate similarly across the cell cycle at either the transcript or the protein level. Ribonucleotide reductase subunit mRNA levels are comparably low in both damaged and undamaged G1 cells and highly induced in damaged S/G2 cells. Transcript numbers becomes correlated with both protein levels and localization only upon DNA damage in a cell cycle-dependent manner. The differential ribonucleotide reductase response to DNA damage correlates with variable Mec1 kinase activity in the cell cycle in single cells. The transcription of ribonucleotide reductase genes is noisy and non-Poissonian in nature Saccharomyces cerevisiae