Cloned (Comment) | Organism |
---|---|
expression analysis of AtRNR2-like catalytic subunit gene AtRNR2A, phylogenetic analysis. Transcriptional changes of 17-days-old Arabidopsis plants, enriched in S-phase cells over younger seedlings, in response to the replication-blocking agent hydroxyurea and to the DNA double-strand break inducer bleomycin | Arabidopsis thaliana |
expression analysis of AtRNR2-like catalytic subunit gene AtRNR2B, phylogenetic analysis. Transcriptional changes of 17-days-old Arabidopsis plants, enriched in S-phase cells over younger seedlings, in response to the replication-blocking agent hydroxyurea and to the DNA double-strand break inducer bleomycin | Arabidopsis thaliana |
expression analysis of the AtRNR2-like catalytic subunit gene TSO2, phylogenetic analysis. Transcriptional changes of 17-days-old Arabidopsis plants, enriched in S-phase cells over younger seedlings, in response to the replication-blocking agent hydroxyurea and to the DNA double-strand break inducer bleomycin | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | atTSO2 transcription is only activated in response to double-strand breaks dependent upon AtE2Fa. ATso2 mutant is hypersensitive to bleomycin, transgenic plant phenotypes, overview | Arabidopsis thaliana |
additional information | early AtRNR2A induction is decreased in an atr mutant, rnr2a mutants are hypersensitive to hydroxyurea, transgenic plant phenotypes, overview | Arabidopsis thaliana |
morme | AtRNR2B induction is abolished in the rad9-rad17 double mutant, transgenic plant phenotypes, overview | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Arabidopsis thaliana | RNR is an essential enzyme that provides dNTPs for DNA replication and repair, regulation in response to genotoxic stress, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | P0DKH2 | small subunit B, R2B; var. Columbia, ecotype Columbia-0, three AtRNR2-like catalytic subunit genes AtTSO2, AtRNR2A, and AtRNR2B | - |
Arabidopsis thaliana | P50651 | small subunit A, R2A; var. Columbia, ecotype Columbia-0, three AtRNR2-like catalytic subunit genes AtTSO2, AtRNR2A, and AtRNR2B | - |
Arabidopsis thaliana | Q9LSD0 | small subunit C, TSO2; var. Columbia, ecotype Columbia-0, three AtRNR2-like catalytic subunit genes AtTSO2, AtRNR2A, and AtRNR2B | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | RNR is an essential enzyme that provides dNTPs for DNA replication and repair, regulation in response to genotoxic stress, overview | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ribonucleotide reductase | - |
Arabidopsis thaliana |
RNR2 | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
physiological function | RNR is an essential enzyme that provides dNTPs for DNA replication and repair, AtRNR2A induction is likely required for the replicative stress checkpoint. Individual RNR2-like catalytic subunit genes participate in unique aspects of the cellular response to DNA damage in Arabidopsis thaliana | Arabidopsis thaliana |
physiological function | RNR is an essential enzyme that provides dNTPs for DNA replication and repair, TSO2 and E2Fa are likely required for the DNA damage response. Individual RNR2-like catalytic subunit genes participate in unique aspects of the cellular response to DNA damage in Arabidopsis thaliana | Arabidopsis thaliana |
physiological function | RNR is an essential enzyme that provides dNTPs for DNA replication and repair. Individual RNR2-like catalytic subunit genes participate in unique aspects of the cellular response to DNA damage in Arabidopsis thaliana | Arabidopsis thaliana |