Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-aminopyridine-2-carboxaldehyde thiosemicarbazone | i.e.3-AP or triapine, in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive myeloprol, phase I study, detailed overview, the inhibitor inhibits the M2 subunit, and depletes intracellular deoxyribonculeotide pools, especially dATP | Homo sapiens | |
Hydroxyurea | inhibits the M2 subunit | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
adults with refractory acute leukemias and aggressive myeloproliferative disorders, MPD | - |
Subunits | Comment | Organism |
---|---|---|
tetramer | 2 * M1-subunit + 2 * M2-subunit | Homo sapiens |