Literature summary for 1.17.4.1 extracted from

Fuertes, M.J.; Kaur, J.; Deb, P.; Cooperman, B.S.; Smith, A.B.
Design, synthesis, and evaluation of octahydropyranopyrrole-based inhibitors of mammalian ribonucleotide reductase (2005), Bioorg. Med. Chem. Lett., 15, 5146-5149.

Inhibitors

Inhibitors	Comment	Organism	Structure
N-[[(3S,5S,7S,7aS)-7-([[3-(9H-fluoren-9-yl)propanoyl]oxy]methyl)-3-hydroxy-5-(2-methylpropoxy)hexahydropyrano[3,4-b]pyrrol-1(2H)-yl]acetyl]-L-alpha-aspartyl-L-phenylalanine	50% inhibition at 0.04-0.05 mM, bicyclic scaffold is necessary to maintain inhibitory activity	Mus musculus

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

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Release 2023.1 (January 2023)