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Literature summary for 1.17.4.1 extracted from

  • Shao, J.; Zhou, B.; Zhu, L.; Bilio, A.J.; Su, L.; Yuan, Y.C.; Ren, S.; Lien, E.J.; Shih, J.; Yen, Y.
    Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay (2005), Biochem. Pharmacol., 69, 627-634.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
deferoxamine mesylate IC50 for subunit p53R2 is 0.00316 mM, IC50 for hRRM2 subunit is 0.5 mM Homo sapiens
Hydroxyurea IC50 for subunit p53R2 is 2.48 mM, IC50 for hRRM2 subunit is 0.991 mM Homo sapiens
triapine IC50 for subunit p53R2 is 112 nM, IC50 for hRRM2 subunit is 144 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP + reduced thioredoxin
-
Homo sapiens 2'-dCDP + thioredoxin disulfide + H2O
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