Literature summary for 1.17.4.1 extracted from

Whitefield, J.F.; Sikorska, M.; Youdale, T.; Brewer, L.; Richards, R.; Walker, P.R.
Ribonucleotide reductase - new twists in an old tale (1989), Adv. Enzyme Regul., 28, 113-123.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	non-proliferating cells inactivate 88000-90000 Da M1 subunit by degradation into 40000 Da fragments	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ribonucleoside diphosphate + reduced thioredoxin	-	Rattus norvegicus	2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O	-	ir

Subunits

Subunits	Comment	Organism
More	88000-90000 Da M1 subunits are degraded into 40000 Da fragments in proliferately quiescent liver cells, intact subunits are only accumulated when the cells replicate DNA	Rattus norvegicus

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Release 2023.1 (January 2023)