Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole | noncompetitive vs. CDP | Herpes simplex virus | |
3,5-diamino-1H-1,2,4-triazole | noncompetitive vs. CDP; trivial name guanazole | Herpes simplex virus | |
4-Methyl-5-amino-1-formylisoquinoline thiosemicarbazone | inactivation, half-life: 3 min | Herpes simplex virus | |
additional information | mechanism studied with inhibitors | Herpes simplex virus | |
Periodate-oxidized inosine | inactivation, 1 mM, half-life: 6 min | Herpes simplex virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Herpes simplex virus | - |
type 1, HSV-1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ribonucleoside diphosphate + reduced thioredoxin | - |
Herpes simplex virus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.1 | - |
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole | derived from slope | Herpes simplex virus | |
1.5 | - |
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole | derived from intercept | Herpes simplex virus | |
14 | - |
guanozole | derived from intercept | Herpes simplex virus | |
27 | - |
guanozole | derived from slope | Herpes simplex virus |