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Literature summary for 1.17.3.2 extracted from
- On-chip assay for determining the inhibitory effects and modes of action of drugs against xanthine oxidase (2010), J. Pharm. Biomed. Anal., 51, 1-6.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aminoglutethimide | - |
Homo sapiens |  |
| cyclosporin A | - |
Homo sapiens | |
| dithranol | - |
Homo sapiens | |
| additional information | development of a photodiode array chip-based xanthine assay for high-throughput screening of xanthiine oxidase inhibitors using a PDA microchip system, mechanism of drug action, enzyme-inhibitor interaction analysis, overview | Homo sapiens | |
| naringenin | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| xanthine + O2 + H2O | Homo sapiens | - |
urate + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| xanthine + O2 + H2O | - |
Homo sapiens | urate + H2O2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | xanthine oxidase is a key enzyme that can catalyze the conversion of xanthine to uric acid, causing various diseases in humans | Homo sapiens |
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Release 2023.1 (January 2023)
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