Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.3.2 extracted from

  • Murata, K.; Nakao, K.; Hirata, N.; Namba, K.; Nomi, T.; Kitamura, Y.; Moriyama, K.; Shintani, T.; Iinuma, M.; Matsuda, H.
    Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle (2009), J. Nat. Med., 63, 355-359.
    View publication on PubMed
Search for more literature for 1.17.3.2

Inhibitors

Inhibitors Comment Organism Structure
allopurinol
-
 Bos taurus
hydroxychavicol i.e. 4-allyl-1,3-hydroxybenzene, a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle. Structure-activity relationships, the dihydroxyl group is required for the xanthine oxidase inhibitory activity, overview Bos taurus
additional information eugenol, methyleugenol, and dihydromethyleugenol are poor inhibitors Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + O2 + H2O Bos taurus
-
 urate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + O2 + H2O
-
 Bos taurus urate + H2O2
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0167
-
-
 Bos taurus hydroxychavicol
0.0307
-
-
 Bos taurus allopurinol

General Information

General Information Comment Organism
metabolism xanthine oxidase is a key enzyme in the purine metabolic pathway, catalysing the oxidation of hypoxanthine to uric acid Bos taurus