Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.3.2 extracted from

  • Millar, T.M.
    Peroxynitrite formation from the simultaneous reduction of nitrite and oxygen by xanthine oxidase (2004), FEBS Lett., 562, 129-133.
    View publication on PubMed
Search for more literature for 1.17.3.2

Inhibitors

Inhibitors Comment Organism Structure
allopurinol inhibits peroxynitrite generation, IC50: 0.007 mM Bos taurus
diphenylene iodonium inhibits peroxynitrite generation Bos taurus
Superoxide dismutase inhibits peroxynitrite generation Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
 hypoxanthine
-
 Bos taurus
0.026
-
 O2 with xanthine as cosubstrate Bos taurus
0.036
-
 pterin
-
 Bos taurus
0.04
-
 nitrite pterin as cosubstrate Bos taurus
0.07
-
 nitrite hypoxanthine as cosubstrate Bos taurus
0.1
-
 O2 with NADH as cosubstrate Bos taurus
1
-
 nitrite with xanthine as cosubstrate Bos taurus
1.2
-
 nitrite with NADH as cosubstrate Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nitrite + NADH
-
 Bos taurus NO + NAD+ + H2O
-
 ?
nitrite + O2 + hypoxanthine
-
 Bos taurus peroxynitrite + ?
-
 ?
nitrite + O2 + pterin
-
 Bos taurus peroxynitrite + ?
-
 ?
nitrite + xanthine
-
 Bos taurus NO + ?
-
 ?
xanthine + H2O + O2
-
 Bos taurus urate + H2O2
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.007
-
 inhibits peroxynitrite generation, IC50: 0.007 mM Bos taurus allopurinol