General Stability | Organism |
---|---|
heparin-Sepharose 6B-bound enzyme, half-life: 120 h and 67 h at 4°C and 20°C respectively, free enzyme, 61 h and 45 h at 4°C and 67°C respectively | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
xanthine | - |
Homo sapiens | |
0.015 | - |
xanthine | heparin-Sepharose 6B-bound enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | enzyme binds to endothelial cells in a partially heparin-reversible manner | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | iron-molybdenum protein | Homo sapiens | |
Molybdenum | an iron-molybdenum protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | - |
Homo sapiens |
proteolytic modification | - |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxanthine + 2 H2O + 2 O2 | - |
Homo sapiens | urate + 2 H2O2 | - |
? | |
xanthine + H2O + O2 | electron acceptor O2 | Homo sapiens | uric acid + H2O2 | enzyme contributes to the oxidant stress component of ischemia-reperfusion injury to intestine and liver, O2- production decreases with increasing substrate concentrations | ? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | flavoprotein | Homo sapiens |