Any feedback?
Literature summary for 1.17.2.1 extracted from
- Deciphering the genetic determinants for aerobic nicotinic acid degradation: The nic cluster from Pseudomonas putida KT2440 (2008), Proc. Natl. Acad. Sci. USA, 105, 11329-11334.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 12800 | - |
x * 23800, small subunit NicA, + x * 12800, large subunit NicB | Pseudomonas putida |
| 23800 | - |
x * 23800, small subunit NicA, + x * 12800, large subunit NicB | Pseudomonas putida |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas putida | - |
KT2440 | - |
| Pseudomonas putida KT 2240 | - |
KT2440 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-cyanopyridine + 5-methylphenazinium methyl sulfate + H2O | 4% of the activity with nicotinate | Pseudomonas putida | ? | - |
? |  |
| nicotinic acid + 5-methylphenazinium methyl sulfate + H2O | - |
Pseudomonas putida | 6-hydroxynicotinic acid + ? | - |
? | |
| nipecotic acid + 5-methylphenazinium methyl sulfate + H2O | 8% of the activity with nicotinate | Pseudomonas putida | ? | - |
? | |
| picolinic acid + 5-methylphenazinium methyl sulfate + H2O | 7% of the activity with nicotinate | Pseudomonas putida | ? | - |
? | |
| pyrazine-2-carboxylic acid + 5-methylphenazinium methyl sulfate + H2O | 8% of the activity with nicotinate | Pseudomonas putida | ? | - |
? | |
| pyridine-3-carboxyaldehyde + 5-methylphenazinium methyl sulfate + H2O | 5% of the activity with nicotinate | Pseudomonas putida | ? | - |
? | |
| pyridine-3-sulfonic acid + 5-methylphenazinium methyl sulfate + H2O | 4% of the activity with nicotinate | Pseudomonas putida | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 23800, small subunit NicA, + x * 12800, large subunit NicB | Pseudomonas putida |
| More | small subunit NicA harbors the 41-C-X4-C-G-X-C-Xn-C-59 and 100-C-G-X-C-X31-C-X-C-137 conserved motifs likely involved in binding of the two [2Fe-2S] clusters | Pseudomonas putida |
| More | the N-terminal region of large subunit NicB contains the active site and the molybdopterin cytosine dinucleotide binding sites in an arrangement MPT2-MPT1-MPT3. The C-terminal region of NicB, residues750-1187, contains three conserved cytochrome c hemebinding motifs 817-CAVCH-823, 963-CTACH-969, and 1087-CLGCH-1093 | Pseudomonas putida |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NicA | - |
Pseudomonas putida |
| NicB | - |
Pseudomonas putida |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Pseudomonas putida |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Pseudomonas putida |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 2Fe-2S-center | - |
Pseudomonas putida | |
| cytochrome c | - |
Pseudomonas putida | |
| molybdopterin cytosine dinucleotide | - |
Pseudomonas putida | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
