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Literature summary for 1.17.1.8 extracted from

  • Bartlett, A.T.M.; White, P.J.
    Regulation of the enzymes of lysine biosynthesis in Bacillus sphaericus NCTC 9602 during vegetative growth (1986), J. Gen. Microbiol., 132, 3169-3177.
No PubMed abstract available
Search for more literature for 1.17.1.8

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Lysinibacillus sphaericus
dipicolinate
-
 Lysinibacillus sphaericus
additional information not inhibited by lysine, methionine and threonine Lysinibacillus sphaericus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-dihydrodipicolinate + NAD(P)H Lysinibacillus sphaericus highest activity during exponential growth phase 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?
2,3-dihydrodipicolinate + NAD(P)H Lysinibacillus sphaericus repressed by lysine 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?

Organism

Organism UniProt Comment Textmining
Lysinibacillus sphaericus
-
 NCTC 9602
-

Reaction

Reaction Comment Organism Reaction ID
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ partly repressed by lysine Lysinibacillus sphaericus
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.029
-
 during stationary phase Lysinibacillus sphaericus
0.04
-
 during late exponential phase Lysinibacillus sphaericus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-dihydrodipicolinate + NAD(P)H
-
 Lysinibacillus sphaericus 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?
2,3-dihydrodipicolinate + NAD(P)H highest activity during exponential growth phase Lysinibacillus sphaericus 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?
2,3-dihydrodipicolinate + NAD(P)H repressed by lysine Lysinibacillus sphaericus 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Lysinibacillus sphaericus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
 Lysinibacillus sphaericus