Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.1.4 extracted from

  • Kaminsky, Y.; Kosenko, C.I.e.
    Brain purine metabolism and xanthine dehydrogenase/oxidase conversion in hyperammonemia are under control of NMDA receptors and nitric oxide (2009), Brain Res., 1294, 193-201.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
sodium nitroprusside i.e. SNP, a NO donor, activates at concentrations of up to 3 mM, preventable by hemoglobin, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ammonium acetate inhibits the enzyme in vivo after injection into the brain, blocked by MK-801, which alone does not affect the enzyme activity itself Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + NAD+ + H2O Rattus norvegicus
-
urate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
forebrain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + NAD+ + H2O
-
Rattus norvegicus urate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
xanthine:NAD+ oxidoreductase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus

General Information

General Information Comment Organism
metabolism xanthine dehydrogenase is an enzyme form of the xanthine dehydrogenase/oxidase enzyme, XDH, complex, that catalyzes the end step in the purine catabolic pathway and is directly involved in depletion of the adenylate pool in the cell Rattus norvegicus