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Literature summary for 1.17.1.4 extracted from

  • Wajner, M.; Harkness, R.A.
    Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues (1989), Biochim. Biophys. Acta, 991, 79-84.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol 100000 x g supernatant, cerebral cortex, liver Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + NAD+ + H2O Homo sapiens
-
urate + NADH
-
r
xanthine + NAD+ + H2O Oryctolagus cuniculus
-
urate + NADH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
dehydrogenase activity predominant form
-
Oryctolagus cuniculus
-
rabbit
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-
cerebellum
-
Oryctolagus cuniculus
-
cerebellum high rate of dehydrogenase activity Homo sapiens
-
cerebral cortex
-
Oryctolagus cuniculus
-
cerebral cortex high rate of dehydrogenase activity Homo sapiens
-
heart
-
Oryctolagus cuniculus
-
heart high rate of dehydrogenase activity Homo sapiens
-
kidney
-
Homo sapiens
-
liver high oxidase and reductase activities at nearly the same rates Homo sapiens
-
liver high oxidase and reductase activities at nearly the same rates Oryctolagus cuniculus
-
placenta very low oxidase and dehydrogenase activities Homo sapiens
-
pons
-
Oryctolagus cuniculus
-
pons high rate of dehydrogenase activity Homo sapiens
-
skeletal muscle low oxidase activity Homo sapiens
-
small intestine
-
Homo sapiens
-
spleen
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + NAD+ + H2O
-
Homo sapiens urate + NADH
-
r
xanthine + NAD+ + H2O
-
Oryctolagus cuniculus urate + NADH
-
r

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
-20
-
stable up to 10 days Homo sapiens
4
-
liver extract: conversion of dehydrogenase to oxidase activity, some loss of activity after 7 days, extract from cerebrellum and cerebral cortex: stable for 7 days Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6 9.2 trends to increasing activities at higher values Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Oryctolagus cuniculus
NADH
-
Homo sapiens
NADH
-
Oryctolagus cuniculus