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Literature summary for 1.16.3.1 extracted from

  • Huang, C.; Lee, I.; Yeh, I.; Liao, J.; Ni, C.; Wu, S.; Chiou, S.
    Upregulation of a non-heme iron-containing ferritin with dual ferroxidase and DNA-binding activities in Helicobacter pylori under acid stress (2010), J. Biochem., 147, 535-543.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression of His-tagged enzyme in Escherichia coli strain BL21(DE3) Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Helicobacter pylori the non-heme iron-containing ferritin has dual ferroxidase and DNA-binding activities, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
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Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography Helicobacter pylori

Source Tissue

Source Tissue Comment Organism Textmining
additional information HD103, a clinical isolate obtained from gastrointestinal biopsy specimens of a patient with duodenal ulcer Helicobacter pylori
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the non-heme iron-containing ferritin has dual ferroxidase and DNA-binding activities, overview Helicobacter pylori ?
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 ?

Expression

Organism Comment Expression
Helicobacter pylori the enzyme expression is upregulated under acid stress at pH 5.0 compared to pH 7.0 up

General Information

General Information Comment Organism
additional information the organism contains a non-heme iron-containing ferritin with dual ferroxidase and DNA-binding activities, that is upregulate under acid stress, overview. By its binding to DNA under acid stress, HP-ferritin is able to protect DNA from oxidative damage caused by free radicals in the presence of metal ions such as iron and copper, overview Helicobacter pylori
physiological function the non-heme iron-binding ferritin with dual ferroxidase and DNA-binding functionality reported herein, may play a significant urease-independent role in the acid adaptation of Helicobacter pylori under physiological conditions in vivo Helicobacter pylori