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Literature summary for 1.16.3.1 extracted from
- Ceruloplasmin: the copper transport protein with essential oxidase activity (1976), Adv. Enzymol. Relat. Areas Mol. Biol., 44, 187-236.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | clinical interest relates to its critical role in the diagnosis of Wilson's disease in serum from patients, marked reduction in serum of patients | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-aminohexanoic acid | - |
Homo sapiens |  |
| Al3+ | strong inhibitor | Homo sapiens | |
| Ba2+ | weak inhibitor | Homo sapiens | |
| Ca2+ | weak inhibitor | Homo sapiens | |
| Ce3+ | strong inhibitor | Homo sapiens | |
| Cr3+ | strong inhibitor | Homo sapiens | |
| Ga3+ | strong inhibitor | Homo sapiens | |
| In3+ | strong inhibitor | Homo sapiens | |
| K+ | weak inhibitor | Homo sapiens | |
| La3+ | strong inhibitor | Homo sapiens | |
| Li+ | weak inhibitor | Homo sapiens | |
| Na+ | weak inhibitor | Homo sapiens | |
| Rh3+ | strong inhibitor | Homo sapiens | |
| Sc3+ | strong inhibitor | Homo sapiens | |
| Sn2+ | weak inhibitor | Homo sapiens | |
| VO2+ | strong inhibitor | Homo sapiens | |
| Y3+ | strong inhibitor | Homo sapiens | |
| ZrO2+ | strong inhibitor | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0006 | - |
Fe2+ | pH 6.5, 30°C, 2 Km-values: 0.0006 and 0.050 mM | Homo sapiens | |
| 0.00126 | - |
2-nitro-p-phenylenediamine | - |
Homo sapiens | |
| 0.0013 | - |
promazine | - |
Homo sapiens | |
| 0.0013 | - |
perphenazine | - |
Homo sapiens | |
| 0.0014 | - |
thioridazine | - |
Homo sapiens | |
| 0.0014 | - |
alimemazine | - |
Homo sapiens | |
| 0.00154 | - |
p-Aminophenol | - |
Homo sapiens | |
| 0.002 | - |
periciazine | - |
Homo sapiens | |
| 0.0023 | - |
Promethazine | - |
Homo sapiens | |
| 0.0023 | - |
diethazine | - |
Homo sapiens | |
| 0.00255 | - |
L-epinephrine | - |
Homo sapiens | |
| 0.00262 | - |
2-sulfonic acid-p-phenylenediamine | - |
Homo sapiens | |
| 0.0028 | - |
Trifluoperazine | - |
Homo sapiens | |
| 0.00281 | - |
L-norepinephrine | - |
Homo sapiens | |
| 0.00285 | - |
3,4-Dihydroxyphenethylamine | - |
Homo sapiens | |
| 0.00288 | - |
o-aminophenol | - |
Homo sapiens | |
| 0.00295 | - |
o-phenylenediamine | - |
Homo sapiens | |
| 0.00305 | - |
N,N-dimethyl-m-phenylenediamine | - |
Homo sapiens | |
| 0.0035 | - |
chlorpromazine | - |
Homo sapiens | |
| 0.005 | - |
fluphenazine | - |
Homo sapiens | |
| 0.0051 | - |
5-hydroxytryptophol | - |
Homo sapiens | |
| 0.0052 | - |
ascorbate | - |
Homo sapiens | |
| 0.00614 | - |
p-anisidine | - |
Homo sapiens | |
| 0.00834 | - |
5-hydroxyindol-3-ylacetic acid | - |
Homo sapiens | |
| 0.01 | - |
triflupromazine | - |
Homo sapiens | |
| 0.0123 | - |
N-acetyl-p-phenylenediamine | - |
Homo sapiens | |
| 0.0163 | - |
5-hydroxytryptophan | - |
Homo sapiens | |
| 0.021 | - |
N-(p-methoxyphenyl)p-phenylenediamine | - |
Homo sapiens | |
| 0.036 | - |
m-phenylenediamine | - |
Homo sapiens | |
| 0.048 | - |
N-phenyl-p-phenylenediamine | - |
Homo sapiens | |
| 0.05 | - |
Fe2+ | pH 6.5, 30°C, 2 Km-values: 0.0006 and 0.050 mM | Homo sapiens | |
| 0.0579 | - |
pyrogallol | - |
Homo sapiens | |
| 0.0603 | - |
4-methylcatechol | - |
Homo sapiens | |
| 0.0657 | - |
quinone | - |
Homo sapiens | |
| 0.087 | - |
N-ethyl-N-2(S-methylsulfonamido)-ethyl-p-phenylenediamine | - |
Homo sapiens | |
| 0.11 | - |
N-ethyl-N-(2-hydroxyethyl)p-phenylenediamine | - |
Homo sapiens | |
| 0.161 | - |
2-methoxy-p-phenylenediamine | - |
Homo sapiens | |
| 0.164 | - |
N,N'-dimethyl-p-phenylenediamine | - |
Homo sapiens | |
| 0.171 | - |
durenediamine | - |
Homo sapiens | |
| 0.18 | - |
o-Dianisidine | - |
Homo sapiens | |
| 0.197 | - |
N,N,N',N'-tetramethyl-p-phenylenediamine | - |
Homo sapiens | |
| 0.203 | - |
N,N-Dimethyl-p-phenylenediamine | - |
Homo sapiens | |
| 0.213 | - |
2-methyl-p-phenylenediamine | - |
Homo sapiens | |
| 0.241 | - |
2-chloro-p-phenylenediamine | - |
Homo sapiens | |
| 0.282 | - |
catechol | - |
Homo sapiens | |
| 0.292 | - |
p-phenylenediamine | - |
Homo sapiens | |
| 0.556 | - |
N,N-diethyl-p-phenylenediamine | - |
Homo sapiens | |
| 0.9 | - |
prochlorperazine | - |
Homo sapiens | |
| 0.908 | - |
5-hydroxytryptamine | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | activating | Homo sapiens | |
| Co2+ | activating | Homo sapiens | |
| Cu2+ | - |
Homo sapiens | |
| Fe2+ | - |
Homo sapiens | |
| Mg2+ | activating | Homo sapiens | |
| Mn2+ | activating | Homo sapiens | |
| Ni2+ | activating | Homo sapiens | |
| Zn2+ | activating | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 16000 | - |
2 * 16000 + 2 * 35000, SDS-PAGE | Homo sapiens |
| 17000 | - |
1 * 17000 + 1 * 59000 | Homo sapiens |
| 24000 | - |
1 * 24000 + 1 * 93000, cleaved by protease | Homo sapiens |
| 35000 | - |
2 * 16000 + 2 * 35000, SDS-PAGE | Homo sapiens |
| 59000 | - |
1 * 17000 + 1 * 59000 | Homo sapiens |
| 93000 | - |
1 * 24000 + 1 * 93000, cleaved by protease | Homo sapiens |
| 124000 | - |
- |
Rattus norvegicus |
| 124000 | - |
nonproteolyzed single-chain, sedimentation equilibrium | Homo sapiens |
| 132000 | - |
- |
Homo sapiens |
| 134000 | - |
nonproteolyzed single-chain, sedimentation equilibrium | Homo sapiens |
| 150000 | - |
- |
Homo sapiens |
| 150000 | - |
- |
Sus scrofa |
| 160000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Fe2+ + H+ + O2 | Homo sapiens | - |
Fe3+ + H2O | - |
? | |
| Fe2+ + H+ + O2 | Rattus norvegicus | - |
Fe3+ + H2O | - |
? | |
| Fe2+ + H+ + O2 | Sus scrofa | - |
Fe3+ + H2O | - |
? | |
| Fe2+ + H+ + O2 | Oryctolagus cuniculus | - |
Fe3+ + H2O | - |
? | |
| Fe2+ + H+ + O2 | Rana sp. | - |
Fe3+ + H2O | - |
? | |
| Fe2+ + H+ + O2 | Equus sp. | - |
Fe3+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus sp. | - |
horse | - |
| Homo sapiens | - |
human | - |
| Homo sapiens | - |
Cohn's fraction F-IV-1 of normal human pooled plasma | - |
| no activity in Rana catesbeiana | - |
bullfrog | - |
| Oryctolagus cuniculus | - |
- |
- |
| Rana sp. | - |
frog | - |
| Rattus norvegicus | - |
rat | - |
| Sus scrofa | - |
hog | - |
| Sus scrofa | - |
pig, porcine | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
| blood | - |
Sus scrofa | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| plasma | - |
Homo sapiens | - |
| plasma | - |
Rattus norvegicus | - |
| plasma | - |
Sus scrofa | - |
| serum | - |
Homo sapiens | - |
| serum | - |
Rattus norvegicus | - |
| serum | - |
Sus scrofa | - |
| serum | - |
Oryctolagus cuniculus | - |
| serum | - |
Equus sp. | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 0.1 M Tris buffer, pH 8.0, decomposes into fragments when stored for 36-48 h | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-chloro-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 2-methoxy-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 2-methyl-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 2-nitro-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 2-sulfonic acid-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 3,4-dihydroxyphenethylamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 4-methylcatechol + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 5-hydroxyindol-3-ylacetic acid + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 5-hydroxytryptamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 5-hydroxytryptophan + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| 5-hydroxytryptophol + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| alimemazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| ascorbate + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| ascorbate + Fe2+ + O2 | - |
Sus scrofa | ? | - |
? | |
| catechol + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| chlorpromazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| diethazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| durenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| Fe2+ + H+ + O2 | - |
Homo sapiens | Fe3+ + H2O | - |
? | |
| Fe2+ + H+ + O2 | - |
Rattus norvegicus | Fe3+ + H2O | - |
? | |
| Fe2+ + H+ + O2 | - |
Sus scrofa | Fe3+ + H2O | - |
? | |
| Fe2+ + H+ + O2 | - |
Oryctolagus cuniculus | Fe3+ + H2O | - |
? | |
| Fe2+ + H+ + O2 | - |
Rana sp. | Fe3+ + H2O | - |
? | |
| Fe2+ + H+ + O2 | - |
Equus sp. | Fe3+ + H2O | - |
? | |
| fluphenazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| L-epinephrine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| L-norepinephrine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| m-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| additional information | - |
Sus scrofa | ? | - |
? | |
| additional information | multifunctional protein, copper transport, molecule directly involved in iron mobilization to the plasma by means of its ferroxidase activity, regulator of circulating biogenic amine levels through its oxidase activity | Homo sapiens | ? | - |
? | |
| N,N'-dimethyl-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| N,N,N',N'-tetramethyl-p-phenylenediamine + Fe2+ | - |
Homo sapiens | ? | - |
? | |
| N,N-diethyl-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| N,N-dimethyl-m-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| N,N-dimethyl-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| N-(p-methoxyphenyl)-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| N-acetyl-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| N-ethyl-N-(2-hydroxyethyl)-p-phenylenediamine Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| N-ethyl-N-(2-hydroxyethyl)p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
r | |
| N-ethyl-N-2(S-methylsulfonamido)-ethyl-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| N-phenyl-p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| o-aminophenol + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| o-dianisidine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| o-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| p-aminophenol + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| p-anisidine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| p-phenylenediamine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| p-phenylenediamine + Fe2+ + O2 | - |
Sus scrofa | ? | - |
? | |
| periciazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| perphenazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| prochlorperazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| promazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| prometazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| pyrogallol + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| quinone + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| thioridazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| trifluoperazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
| triflupromazine + Fe2+ + O2 | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 17000 + 1 * 59000 | Homo sapiens |
| dimer | 1 * 24000 + 1 * 93000, cleaved by protease | Homo sapiens |
| monomer | - |
Homo sapiens |
| monomer | - |
Sus scrofa |
| monomer | - |
Oryctolagus cuniculus |
| monomer | - |
Equus sp. |
| tetramer | 2 * 16000 + 2 * 35000, SDS-PAGE | Homo sapiens |
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