Literature summary for 1.16.1.8 extracted from

Kim, D.J.; Park, B.L.; Koh, J.M.; Kim, G.S.; Kim, L.H.; Cheong, H.S.; Shin, H.D.; Hong, J.M.; Kim, T.H.; Shin, H.I.; Park, E.K.; Kim, S.Y.
Methionine synthase reductase polymorphisms are associated with serum osteocalcin levels in postmenopausal women (2006), Exp. Mol. Med., 38, 519-524.

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Application

Application	Comment	Organism
medicine	study on association of natural polymorphisms I22M (A66G) and S175L (C524T) with bone mineral density and serum osteocalcin levels. No significant association between these two polymorphisms and bone mineral density and serum osteocalcin levels, but the 66G/524C haplotype affects bone turnover rate	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
I22M	natural occuring polymorphism, no significant association with bone mineral density or serum osteocalcin level	Homo sapiens
S175L	natural occuring polymorphism, no significant association with bone mineral density or serum osteocalcin level	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	postmenopausal women, certain genetic polymorphisms of enzyme leading to a reduced activity may cause hyperhomocysteinemia and affect bone metabolism	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
MTRR	-	Homo sapiens

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Release 2023.1 (January 2023)