KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0023 | - |
2,6-dichlorophenolindophenol | variant I22/S175 | Homo sapiens | |
0.0038 | - |
2,6-dichlorophenolindophenol | variant I22/S175 | Homo sapiens | |
0.0177 | - |
menadione | variant I22/S175 | Homo sapiens | |
0.0177 | - |
3-acetylpyridine adenine dinucleotide phosphate | variant I22/S175 | Homo sapiens | |
0.018 | - |
menadione | variant I22/S175 | Homo sapiens | |
0.018 | - |
3-acetylpyridine adenine dinucleotide phosphate | variant I22/S175 | Homo sapiens | |
0.0286 | - |
doxorubicin | variant I22/S175 | Homo sapiens | |
0.0366 | - |
doxorubicin | variant I22/S175 | Homo sapiens | |
0.663 | - |
ferricyanide | variant I22/S175 | Homo sapiens | |
0.774 | - |
ferricyanide | variant I22/S175 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | difference in the relative efficiency of the very common polymorphic variant of the enzyme, I22M, suggests a molecular mechanism underlying the risk associated wiith the M22 allele for mild hyperhomocysteinemia | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UBK8 | variant I22/S175 | - |
Homo sapiens | Q9UBK8 | variant M22/S175 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | difference in the relative efficiency of the very common polymorphic variant of the enzyme, I22M, suggests a molecular mechanism underlying the risk associated wiith the M22 allele for mild hyperhomocysteinemia | Homo sapiens | ? | - |
? | |
[methionine synthase]-cob(II)alamin + S-adenosyl-L-methionine + 2,6-dichlorophenolindophenol | - |
Homo sapiens | [methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + ? | - |
? | |
[methionine synthase]-cob(II)alamin + S-adenosyl-L-methionine + 3-acetylpyridine adenine dinucleotide phosphate | - |
Homo sapiens | [methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + ? | - |
? | |
[methionine synthase]-cob(II)alamin + S-adenosyl-L-methionine + doxorubicin | - |
Homo sapiens | [methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + ? | - |
? | |
[methionine synthase]-cob(II)alamin + S-adenosyl-L-methionine + ferricyanide | - |
Homo sapiens | [methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + ? | - |
? | |
[methionine synthase]-cob(II)alamin + S-adenosyl-L-methionine + menadione | - |
Homo sapiens | [methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MSR | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.43 | - |
2,6-dichlorophenolindophenol | variant I22/S175 | Homo sapiens | |
0.86 | - |
3-acetylpyridine adenine dinucleotide phosphate | variant I22/S175 | Homo sapiens | |
1.61 | - |
menadione | variant I22/S175 | Homo sapiens | |
1.61 | - |
doxorubicin | variant I22/S175 | Homo sapiens | |
8.24 | - |
ferricyanide | variant I22/S175 | Homo sapiens |