Literature summary for 1.15.1.2 extracted from

Dey, A.; Jenney, F.E.; Adams, M.W.; Johnson, M.K.; Hodgson, K.O.; Hedman, B.; Solomon, E.I.
Sulfur K-edge X-ray absorption spectroscopy and density functional theory calculations on superoxide reductase: role of the axial thiolate in reactivity (2007), J. Am. Chem. Soc., 129, 12418-12431.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	kinetic analysis, binding parameters, and electrochemic parameters of the enzyme and Fe2+ complexes, overview	Pyrococcus furiosus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	1Fe SOR is a non-heme iron enzyme, iron binding and reaction mechanism, detailed overview	Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
reduced rubredoxin + superoxide + H+	Pyrococcus furiosus	-	rubredoxin + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Pyrococcus furiosus	P82385	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin	reaction mechanism of SOR involving transfer of an electron and two protons to superoxide to form hydrogen peroxide, kinetic mechanism, detailed overview	Pyrococcus furiosus	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
reduced rubredoxin + superoxide + H+	-	Pyrococcus furiosus	rubredoxin + H2O2	-	?
reduced rubredoxin + superoxide + H+	SOR is a non-heme iron enzyme that reduces superoxide to peroxide at a diffusion-controlled rate, thiolate acts as a covalent anionic ligand. Replacing the thiolate with a neutral noncovalent ligand makes protonation very endothermic and greatly raises the reduction potential,overview	Pyrococcus furiosus	rubredoxin + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
1Fe SOR	-	Pyrococcus furiosus
SOR	-	Pyrococcus furiosus

Cofactor

Cofactor	Comment	Organism	Structure
reduced rubredoxin	-	Pyrococcus furiosus

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Release 2023.1 (January 2023)