Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.15.1.1 extracted from

  • Tuller, E.R.; Beavers, C.T.; Lou, J.R.; Ihnat, M.A.; Benbrook, D.M.; Ding, W.Q.
    Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling (2009), Mol. Pharmacol., 76, 588-595.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene sod-1, expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information deletion analysis of the key DNA binding elements in the SOD-1 gene promoter identifies the distal hypoxia response element, but not the peroxisome proliferator response element or nuclear factor-kappaB element, as essential for the suppressive effects of docosahexaenoic acid Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
gene sod-1
-

Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell an ovarian carcinoma cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
SOD 1
-
Homo sapiens
superoxide dismutase 1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens docosahexaenoic acid inhibits enzyme transcription in cancer cells, involvement of hypoxia-inducible factor-2alpha signaling, but not of peroxisome proliferator-activated receptor alpha, overview. Suppression of SOD-1 expression by clofibrate also requires hypoxia-inducible factor-2alpha and the binding element in the SOD-1 promoter down