Cloned (Comment) | Organism |
---|---|
gene sodA, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, semi-quantitative expression analysis | Talaromyces marneffei |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | the residues His47, His49, His64, His72, His81, and Asp121 are involved in metal binding | Talaromyces marneffei | |
Zn2+ | the residues His47, His49, His64, His72, His81, and Asp121 are involved in metal binding | Talaromyces marneffei |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
O2.- + H+ | Talaromyces marneffei | the enzyme contributes to the virulence of many human-pathogenic fungi through its ability to neutralize toxic levels of reactive oxygen species generated by the host | O2 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Talaromyces marneffei | B6QEB3 | gene sodA | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | propagation of the fungus in the Mus musculus macrophage cell line derived from a reticulum sarcoma, J774.1, ATCC TIB-67, the enzyme expression is upregulated during macrophage infection | Talaromyces marneffei | - |
conidium | accumulation of sodA mRNA in conidia, semi-quantitative expression analysis | Talaromyces marneffei | - |
additional information | the enzyme expression is upregulated in the yeast phase | Talaromyces marneffei | - |
mycelium | semi-quantitative expression analysis, the expression is down regulates in the mycelium phase | Talaromyces marneffei | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
O2.- + H+ | - |
Talaromyces marneffei | O2 + H2O2 | - |
? | |
O2.- + H+ | the enzyme contributes to the virulence of many human-pathogenic fungi through its ability to neutralize toxic levels of reactive oxygen species generated by the host | Talaromyces marneffei | O2 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
copper, zinc superoxide dismutase | - |
Talaromyces marneffei |
Cu, Zn SOD | - |
Talaromyces marneffei |
SOD | - |
Talaromyces marneffei |