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Literature summary for 1.15.1.1 extracted from

  • Secondo, A.; De Mizio, M.; Zirpoli, L.; Santillo, M.; Mondola, P.
    The Cu-Zn superoxide dismutase (SOD1) inhibits ERK phosphorylation by muscarinic receptor modulation in rat pituitary GH3 cells (2008), Biochem. Biophys. Res. Commun., 376, 143-147.
    View publication on PubMed
Search for more literature for 1.15.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
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Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ isozyme Cu/Zn-SOD Rattus norvegicus
Zn2+ isozyme Cu/Zn-SOD Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O2.- + H+ Rattus norvegicus SOD1 induces Ca2+ in the cell and inhibits ERK phosphorylation in the P-ERK1/2 pathway by muscarinic receptor M1 modulation in rat pituitary GH3 cells, the effect is enhanced by oxotremorine and partially reverted by pyrenzepine, and independent from increased intracellular calcium concentration, overview O2 + H2O2
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
GH3 cell
-
 Rattus norvegicus
-
additional information the enzyme is secreted by many cellular lines and it is also released trough a calcium-dependent depolarization mechanism involving SNARE protein SNAP 25 Rattus norvegicus
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pituitary gland
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O2.- + H+
-
 Rattus norvegicus O2 + H2O2
-
 ?
O2.- + H+ SOD1 induces Ca2+ in the cell and inhibits ERK phosphorylation in the P-ERK1/2 pathway by muscarinic receptor M1 modulation in rat pituitary GH3 cells, the effect is enhanced by oxotremorine and partially reverted by pyrenzepine, and independent from increased intracellular calcium concentration, overview Rattus norvegicus O2 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
Cu-Zn superoxide dismutase
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 Rattus norvegicus
SOD1
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 Rattus norvegicus