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Literature summary for 1.14.99.48 extracted from

  • Reniere, M.L.; Ukpabi, G.N.; Harry, S.R.; Stec, D.F.; Krull, R.; Wright, D.W.; Bachmann, B.O.; Murphy, M.E.; Skaar, E.P.
    The IsdG-family of haem oxygenases degrades haem to a novel chromophore (2010), Mol. Microbiol., 75, 1529-1538.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.48

Cloned(Commentary)

Cloned (Comment) Organism
-
 Staphylococcus aureus

Crystallization (Commentary)

Crystallization (Comment) Organism
isoform IsdI in complex with heme, heme ruffling and constrained binding of oxygen is consistent with cleavage of the porphyrin ring at the beta- or delta-meso carbon atoms Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus
-
 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus
-
 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus N315
-
 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus N315
-
 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus Q7A649
-
-
Staphylococcus aureus Q7A827 isoform IsdI
-
Staphylococcus aureus N315 Q7A649
-
-
Staphylococcus aureus N315 Q7A827 isoform IsdI
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus N315 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus N315 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?

Synonyms

Synonyms Comment Organism
heme oxygenase (staphylobilin-producing) 1
-
 Staphylococcus aureus
heme oxygenase (staphylobilin-producing) 2
-
 Staphylococcus aureus
isdG
-
 Staphylococcus aureus
isdI
-
 Staphylococcus aureus