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Literature summary for 1.14.99.29 extracted from

  • Vu, V.V.; Emerson, J.P.; Martinho, M.; Kim, Y.S.; Muenck, E.; Park, M.H.; Que, L.
    Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center (2009), Proc. Natl. Acad. Sci. USA, 106, 14814-14819.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.29

Application

Application Comment Organism
medicine inhibition of DOHH leads to a decrease of hypusine-containing eIF5A and inhibition of eukaryotic cell growth, consequently, these results suggest that eIF5A and DOHH could be promising targets for antitumor and anti-HIV-1 therapies Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
for expression in Escherichia coli cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2 Homo sapiens
-
 eukaryotic translation initiation factor eIF-5A hypusine + H2O + A
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2
-
 Homo sapiens eukaryotic translation initiation factor eIF-5A hypusine + H2O + A
-
 ?

Synonyms

Synonyms Comment Organism
deoxyhypusine hydroxylase
-
 Homo sapiens
hDOHH
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 activity assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 activity assay Homo sapiens