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Literature summary for 1.14.99.29 extracted from

  • Cano, V.S.; Jeon, G.A.; Johansson, H.E.; Henderson, C.A.; Park, J.H.; Valentini, S.R.; Hershey, J.W.; Park, M.H.
    Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification (2008), FEBS J., 275, 44-58.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.29

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2 Homo sapiens
-
 eukaryotic translation initiation factor eIF-5A hypusine + H2O + A
-
 ?
eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2 Saccharomyces cerevisiae
-
 eukaryotic translation initiation factor eIF-5A hypusine + H2O + A
-
 ?
additional information Saccharomyces cerevisiae following mutants of human eIF-5A are substrates for DOHH - K47A, K47R, G49A, G52A, K55A, P74A, L91A and L101A ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2
-
 Homo sapiens eukaryotic translation initiation factor eIF-5A hypusine + H2O + A
-
 ?
eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2
-
 Saccharomyces cerevisiae eukaryotic translation initiation factor eIF-5A hypusine + H2O + A
-
 ?
additional information following mutants of human eIF-5A are substrates for DOHH - K47A, K47R, G49A, G52A, K55A, P74A, L91A and L101A Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
deoxyhypusine hydroxylase
-
 Homo sapiens
deoxyhypusine hydroxylase
-
 Saccharomyces cerevisiae
DOHH
-
 Homo sapiens
hDOHH
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 combined deoxyhypusine synthase and hydroxylase assay Homo sapiens
37
-
 combined deoxyhypusine synthase and hydroxylase assay Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 combined deoxyhypusine synthase and hydroxylase assay Homo sapiens
8.5
-
 combined deoxyhypusine synthase and hydroxylase assay Saccharomyces cerevisiae