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Literature summary for 1.14.99.29 extracted from

  • Abbruzzese, A.; Park, M.H.; Beninati, S.; Folk, J.E.
    Inhibition of deoxyhypusine hydroxylase by polyamines and by a deoxyhypusine peptide (1989), Biochim. Biophys. Acta, 997, 248-255.
    View publication on PubMed
Search for more literature for 1.14.99.29

Inhibitors

Inhibitors Comment Organism Structure
1,10-Diaminodecane 94% of initial activity at 2 mM Rattus norvegicus
1,3-diaminopropane 86% of initial activity at 0.5 mM Rattus norvegicus
1,6-diaminohexane 97% of initial activity at 2 mM Rattus norvegicus
1,7-Diaminoheptane 91% of initial activity at 2 mM Rattus norvegicus
1,8-diaminooctane 93% of initial activity at 2 mM Rattus norvegicus
cadaverine 87% of initial activity at 0.5 mM Rattus norvegicus
caldine 47% of initial activity at 0.5 mM Rattus norvegicus
Lys-Thr-Gly-deoxyhypusine-His-Gly-His-Ala-Lys competitive inhibition Cricetulus griseus
additional information no inhibition at 2 mM N-(2-cyanopropyl)-3-cyanopropylamine Rattus norvegicus
N-(2-cyanoethyl)butane-1,4-diamine 80% of initial activity at 2 mM Rattus norvegicus
N-(3-cyanopropyl)propane-1,3-diamine 79% of initial activity at 2 mM Rattus norvegicus
putrescine 85% of initial activity at 0.5 mM Rattus norvegicus
spermidine 58% of initial activity at 0.5 mM Rattus norvegicus
spermine 41% of initial activity at 0.5 mM Rattus norvegicus
thermine 35% of initial activity at 0.5 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ovary
-
 Cricetulus griseus
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N'-(4-aminobutyl)lysine + electron donor + O2 i.e. deoxyhypusine Cricetulus griseus N'-(4-amino-2-hydroxybutyl)lysine + oxidized electron donor + H2O i.e. hypusine ?
N'-(4-aminobutyl)lysine + electron donor + O2 i.e. deoxyhypusine Rattus norvegicus N'-(4-amino-2-hydroxybutyl)lysine + oxidized electron donor + H2O i.e. hypusine ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.5 in 20 mM Tris buffer Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.25
-
 spermine competitive inhibition Rattus norvegicus
0.44
-
 Lys-Thr-Gly-deoxyhypusine-His-Gly-His-Ala-Lys competitive inhibition Cricetulus griseus