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Literature summary for 1.14.99.29 extracted from

  • Clement, P.M.J.; Hanauske-Abel, H.M.; Wolff, E.C.; Kleinman, H.K.; Park, M.H.
    The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro (2002), Int. J. Cancer, 100, 491-498.
    View publication on PubMed
Search for more literature for 1.14.99.29

Application

Application Comment Organism
medicine ciclopirox inhibits cell proliferation and angiogenesis in vitro Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,2'-dipyridyl IC50 0.026 mM Homo sapiens
ciclopirox IC50 0.005 mM, complete inhibition above 0.01 mM Homo sapiens
deferiprone IC50 0.117 mM Homo sapiens
desferrioxamine B IC50 0.016 mM Homo sapiens
mimosine IC50 0.191 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
umbilical vein endothelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N'-(4-aminobutyl)lysine + electron donor + O2 i.e. deoxyhypusine Homo sapiens N'-(4-amino-2-hydroxybutyl)lysine + oxidized electron donor + H2O i.e. hypusine ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.005
-
 IC50 0.005 mM, complete inhibition above 0.01 mM Homo sapiens ciclopirox
0.016
-
 IC50 0.016 mM Homo sapiens desferrioxamine B
0.026
-
 IC50 0.026 mM Homo sapiens 2,2'-dipyridyl
0.117
-
 IC50 0.117 mM Homo sapiens deferiprone
0.191
-
 IC50 0.191 mM Homo sapiens mimosine