Application | Comment | Organism |
---|---|---|
synthesis | CYP199A2 may be a valuable biocatalyst for the regioselective oxidation of various aromatic carboxylic acids | Rhodopseudomonas palustris |
Cloned (Comment) | Organism |
---|---|
CYP199A2 gene RPA1871, coexpression with palustris redoxin gene from Rhodopseudomonas palustris and putidaredoxin reductase gene from Pseudomonas putida to provide the redox partners of CYP199A2 in Escherichia coli | Rhodopseudomonas palustris |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rhodopseudomonas palustris | - |
gene RPA1871 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme performs regioselective oxidation of indole- and quinolinecarboxylic acids, it oxidizes 2-naphthoic acid and 4-ethylbenzoic acid, substrate specificity and regioselectivity of CYP199A2, overview. CYP199A2 does not exhibit any activity towards indole and indole-3-carboxylic acid, whereas this enzyme oxidizes indole-2-carboxylic acid, indole-5-carboxylic acid, and indole-6-carboxylic acid. Indole-2-carboxylic acid is converted to 5- and 6-hydroxyindole-2-carboxylic acids at a ratio of 59:41. In contrast, the indole-6-carboxylic acid oxidation generates only one product, 2-indolinone-6-carboxylic acid. The oxidation product of quinoline-6-carboxylic acid is 3-hydroxyquinoline-6-carboxylic acid | Rhodopseudomonas palustris | ? | - |
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Synonyms | Comment | Organism |
---|---|---|
CYP199A2 | - |
Rhodopseudomonas palustris |
cytochrome P450 199A2 | - |
Rhodopseudomonas palustris |