Any feedback?
Literature summary for 1.14.99.12 extracted from
- Structure-activity relationships in the in vitro modulation of rat hepatic microsomal androst-4-ene-3,17,dione hydroxylase activities by derivatives of 5alpha- and 5beta-androstane (1999), J. Steroid Biochem., 35, 465-471.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5alpha-androstane-17beta-ol | exhibits an IC50 of 0.046 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.026 against androstendione 16alpha-hydroxylase activity and an IC50 of 0.047 against androstendione 16beta-hydroxylase activity | Rattus norvegicus |  |
| 5alpha-androstane-3beta-ol | exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.071 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | |
| 5alpha-androstane-3beta-ol-17-one | exhibits an IC50 of 0.12 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.14 against androstendione 16beta-hydroxylase activity | Rattus norvegicus | |
| 5beta-androstane-17beta-ol | exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.065 against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | |
| 5beta-androstane-3-one-17-one | exhibits an IC50 of 0.084 mM against androstendione 7alpha-hydroxylase activity | Rattus norvegicus | |
| 5beta-androstane-3beta-ol | exhibits an IC50 of 0.027 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.007 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | |
| 5beta-androstane-3beta-ol-17-one | exhibits an IC50 of 0.047 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.06 mM against androstendione 7alpha-hydroxylase activity and an IC50 of 0.051 against androstendione 16alpha-hydroxylase activity and an IC50 of 0.087 against androstendione 16beta-hydroxylase activity; exhibits an IC50 of 0.095 against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | |
| additional information | 5beta-reduced steroids are more potent inhibitors than 5alpha-reduced epimers | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.007 | - |
exhibits an IC50 of 0.027 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.007 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | 5beta-androstane-3beta-ol | |
| 0.026 | - |
IC50 of 0.026 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-17beta-ol | |
| 0.046 | - |
exhibits an IC50 of 0.046 mM against androstendione 6beta-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-17beta-ol | |
| 0.047 | - |
IC50 of 0.047 mM against androstendione 16beta-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-17beta-ol | |
| 0.065 | - |
IC50 of 0.065 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | 5beta-androstane-17beta-ol | |
| 0.071 | - |
exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.071 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-3beta-ol | |
| 0.084 | - |
exhibits an IC50 of 0.084 mM against androstendione 7alpha-hydroxylase activity | Rattus norvegicus | 5beta-androstane-3-one-17-one | |
| 0.095 | - |
exhibits an IC50 of 0.095 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | 5beta-androstane-3beta-ol-17-one | |
| 0.11 | - |
exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity | Rattus norvegicus | 5beta-androstane-17beta-ol | |
| 0.12 | - |
exhibits an IC50 of 0.12 mM against androstendione 6beta-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-3beta-ol-17-one | |
| 0.14 | - |
IC50 of 0.14 mM against androstendione 16beta-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-3beta-ol-17-one | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
