Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glutathione | promotes prostaglandin H synthase-dependent formation of oxidative stress biomarkers malondialdehyde and 15(S)-8-iso-prostaglandin F2alpha | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + 2 O2 | Homo sapiens | - |
prostaglandin G2 + A + ? | - |
? | |
arachidonate + AH2 + 2 O2 | Homo sapiens | - |
prostaglandin H2 + A + H2O | - |
? | |
additional information | Homo sapiens | activity with arachidonate in presence of glutathione leads to formation of malondialdehyde and (15S)-8-iso-prostaglandin F2alpha | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23219 | - |
- |
Homo sapiens | P35354 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + 2 O2 | - |
Homo sapiens | prostaglandin G2 + A + ? | - |
? | |
arachidonate + AH2 + 2 O2 | - |
Homo sapiens | prostaglandin H2 + A + H2O | - |
? | |
additional information | activity with arachidonate in presence of glutathione leads to formation of malondialdehyde and (15S)-8-iso-prostaglandin F2alpha | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
COX | - |
Homo sapiens |
COX-1 | - |
Homo sapiens |
COX-2 | - |
Homo sapiens |
cyclooxygenase | - |
Homo sapiens |
cyclooxygenase-1 | - |
Homo sapiens |
cyclooxygenase-2 | - |
Homo sapiens |
PG H synthase | - |
Homo sapiens |
PGHS | - |
Homo sapiens |
PGHS-1 | - |
Homo sapiens |
PGHS-2 | - |
Homo sapiens |
prostaglandin H synthase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | prostaglandin H synthases or cyclooxygenases catalyse the peroxidation of arachidonic acid to PGG2 and PGH2 which are further converted to a series of prostaglandins and thromboxane A2. The enzyme catalyzes formation of oxidative stress biomarkers malondialdehyde and 15(S)-8-iso-prostaglandin F2alpha, and other F2-isoprostanes, promoted by glutathione | Homo sapiens |