Activating Compound | Comment | Organism | Structure |
---|---|---|---|
arachidonate | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
stable expression of PHS-1 and PHS-2 in CHO-K1 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Acetylsalicylic acid | an irreversible inhibitor of both hPHS-1 and hPHS-2 | Homo sapiens | |
DUP-697 | a PHS-2-specific inhibitor | Homo sapiens | |
SC-560 | a PHS-1-specific inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | Homo sapiens | - |
prostaglandin H2 + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | - |
Homo sapiens | prostaglandin H2 + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PHS-1 | - |
Homo sapiens |
PHS-2 | - |
Homo sapiens |
prostaglandin H synthase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | neurotoxicity of the amphetamine analogues methamphetamine and 3,4-methylenedioxyamphetamine, the active metabolite of ecstasy, may involve their prostaglandin H synthase-dependent bioactivation to free radical intermediates that generate reactive oxygen species and oxidatively damage cellular macromolecules. The activation effect is blocked by irreversible enzyme inhibitor acetylsalicylic acid, overview | Homo sapiens |