Protein Variants | Comment | Organism |
---|---|---|
E488G | site-directed mutagenesis, the mutant shows reduced sensitivity to the cyclooxygenase inhibitor nimesulide compared to the wild-type enzyme. The activity with eicosapentaenoate is altered | Homo sapiens |
G587R | site-directed mutagenesis, the mutant shows reduced sensitivity to the cyclooxygenase inhibitor nimesulide compared to the wild-type enzyme. The activity with eicosapentaenoate is not affected | Homo sapiens |
R228H | site-directed mutagenesis, the mutant shows reduced sensitivity to the cyclooxygenase inhibitor nimesulide compared to the wild-type enzyme. The activity with eicosapentaenoate is not affected | Homo sapiens |
V511A | site-directed mutagenesis, the mutant shows reduced sensitivity to the cyclooxygenase inhibitor nimesulide compared to the wild-type enzyme. The activity with eicosapentaenoate altered | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nimesulide | inhibits the cyclooxygenase activity, a COX-2-specific inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PGHS-2 also shows cyclooxygenase activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PGHS-2 also shows cyclooxygenase activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGHS-2 | - |
Homo sapiens |
prostaglandin H synthase-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PGHS-2 also shows cyclooxygenase activity, which is implicated in colorectal cancer | Homo sapiens |