Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.99.1 extracted from

  • Liu, W.; Poole, E.M.; Ulrich, C.M.; Kulmacz, R.J.
    Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors (2010), Pharmacogenomics J., 11, 337-347.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
E488G site-directed mutagenesis, the mutant shows reduced sensitivity to the cyclooxygenase inhibitor nimesulide compared to the wild-type enzyme. The activity with eicosapentaenoate is altered Homo sapiens
G587R site-directed mutagenesis, the mutant shows reduced sensitivity to the cyclooxygenase inhibitor nimesulide compared to the wild-type enzyme. The activity with eicosapentaenoate is not affected Homo sapiens
R228H site-directed mutagenesis, the mutant shows reduced sensitivity to the cyclooxygenase inhibitor nimesulide compared to the wild-type enzyme. The activity with eicosapentaenoate is not affected Homo sapiens
V511A site-directed mutagenesis, the mutant shows reduced sensitivity to the cyclooxygenase inhibitor nimesulide compared to the wild-type enzyme. The activity with eicosapentaenoate altered Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
nimesulide inhibits the cyclooxygenase activity, a COX-2-specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PGHS-2 also shows cyclooxygenase activity ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PGHS-2 also shows cyclooxygenase activity Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PGHS-2
-
Homo sapiens
prostaglandin H synthase-2
-
Homo sapiens

General Information

General Information Comment Organism
physiological function PGHS-2 also shows cyclooxygenase activity, which is implicated in colorectal cancer Homo sapiens