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Literature summary for 1.14.99.1 extracted from
- The productive conformation of prostaglandin G2 at the peroxidase site of prostaglandin endoperoxide H synthase: docking, molecular dynamics, and site-directed mutagenesis studies (2006), Biochemistry, 45, 811-820.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-1 cells | Homo sapiens |
| into the mammalian expression vector pcDNA3 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K211A | complete abolition of activity | Homo sapiens |
| K211A/K215A | complete abolition of activity | Homo sapiens |
| K211A/K215A/K222A | complete abolition of activity | Homo sapiens |
| K211A/K222A | complete abolition of activity | Homo sapiens |
| K211E | complete abolition of activity | Homo sapiens |
| K211E/K215E | complete abolition of activity | Homo sapiens |
| K211E/K215E/K222E | complete abolition of activity | Homo sapiens |
| K211E/K222E | complete abolition of activity | Homo sapiens |
| K215A | does not impair PGHS activity | Homo sapiens |
| K215A/K222A | significant reduction of 27% of the activity | Homo sapiens |
| K215E | does not impair PGHS activity | Homo sapiens |
| K215E/K222E | significant reduction of 58% of the activity | Homo sapiens |
| K222A | no significant reduction of activity | Homo sapiens |
| K222E | no significant reduction of activity | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aspirin | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe3+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + AH2 + O2 | Homo sapiens | - |
prostaglandin H2 + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
a homology modeling structure of human PGHS-1 is constructed using the Swiss-Model server and the ovine crystal structure 1Q4G as template | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + AH2 + O2 | - |
Homo sapiens | prostaglandin H2 + A + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COX1 | - |
Homo sapiens |
| PGHS | - |
Homo sapiens |
| PGHS-1 | - |
Homo sapiens |
| prostaglandin endoperoxide H synthase-1 | - |
Homo sapiens |
| prostaglandin endoperoxide synthase | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
enzyme-linked immunoassay for PGE2 | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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