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Literature summary for 1.14.99.1 extracted from
- 2.0 A structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor (2006), Acta crystallogr. Sect. D, 62, 151-156.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | clinical important drug target | Ovis aries |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| the 2.0 A resolution crystal structure of the MnIII form of ovine prostaglandin H2 synthase-1 is described | Ovis aries |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| flurbiprofen | cyclooxygenase inhibitor | Ovis aries |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Ovis aries | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe3+ | - |
Ovis aries | |
| Mn3+ | substitution of ferric heme by MnIII protoporphyrin IX greatly diminishes the peroxidase activity, but has little effect on the cyclooxygenase activity | Ovis aries | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + AH2 + O2 | Ovis aries | - |
prostaglandin H2 + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| the apo form of ovine PGHS isoform-1 is purified from ram seminal vesicles, the holoenzyme is reconstituted by adding MnIII-PPIX to the enzyme | Ovis aries |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seminal vesicle | - |
Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + AH2 + O2 | - |
Ovis aries | prostaglandin H2 + A + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PGHS isoform-1 | - |
Ovis aries |
| prostaglandin H2 synthase | - |
Ovis aries |
| prostaglandin H2 synthase-1 | - |
Ovis aries |
| prostaglandin-endoperoxide synthase | - |
Ovis aries |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
cyclooxygenase activity assay | Ovis aries |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Ovis aries | |
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Release 2023.1 (January 2023)
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