Activating Compound | Comment | Organism | Structure |
---|---|---|---|
benzoquinone | stimulates conversion of prostaglandin G1 to H1 | Bos taurus | |
epinephrine | stimulates conversion of prostaglandin G1 to H1 | Bos taurus | |
hydroquinone | stimulates conversion of prostaglandin G1 to H1 | Bos taurus | |
indole | stimulates conversion of prostaglandin G1 to H1 | Bos taurus | |
kynurenine | stimulates conversion of prostaglandin G1 to H1 | Bos taurus | |
Melatonin | stimulates | Bos taurus | |
phenylalanine | stimulates conversion of prostaglandin G1 to H1 | Bos taurus | |
serotonin | stimulates conversion of prostaglandin G1 to H1 | Bos taurus | |
tryptophan | stimulates conversion of prostaglandin G1 to H1 | Bos taurus | |
tyrosine | stimulates conversion of prostaglandin G1 to H1 | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Acetylsalicylic acid | inhibition of prostaglandin G1 synthesis | Bos taurus | |
indomethacin | inhibition of prostaglandin G1 synthesis | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Bos taurus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
300000 | 350000 | gel filtration | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seminal vesicle | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.4 | - |
prostaglandin H1 synthesis | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
8,11,14-eicosatrienoic acid + O2 | bis-dioxygenase activity, cyclooxygenase activity, presence of hematin | Bos taurus | prostaglandin G1 + ? | 9alpha,11alpha-epidioxy-15(S)-hydroperoxy-13-trans-prostenoic acid | ? | |
8,11,14-eicosatrienoic acid + O2 | hydroperoxidase activity, presence of hematin and tryptophan | Bos taurus | prostaglandin H1 + ? | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
pH 8.0, 5 min, complete loss of activity | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
synthesis of prostaglandin G1, conversion to prostaglandin H1 | Bos taurus |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
6 | 8 | 24°C, 5 min, stable | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | either free or protein-bound heme is required for cyclooxygenase- and hydroperoxidase activity | Bos taurus |