Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-ol | selective inhibitors of fungal sterol C22-desaturase. The inhibitor is subjected to antifungal susceptibility testing on patient isolates according to modified EUCAST guidelines. But, the organism shows no significant reduction of cell growth and/or viability up to an inhibitor concentration of 0.1 mg/ml. Thus the sterol C22-desaturase is not an attractive target for the development of antifungals | [Candida] glabrata | |
(3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-ol | selective inhibitors of fungal sterol C22-desaturase. The inhibitor is subjected to antifungal susceptibility testing on patient isolates according to modified EUCAST guidelines. But, the organism shows no significant reduction of cell growth and/or viability up to an inhibitor concentration of 0.1 mg/ml. Thus the sterol C22-desaturase is not an attractive target for the development of antifungals | Saccharomyces cerevisiae | |
(3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-ol | selective inhibitors of fungal sterol C22-desaturase. The inhibitor is subjected to antifungal susceptibility testing on patient isolates according to modified EUCAST guidelines. But, the organism shows no significant reduction of cell growth and/or viability up to an inhibitor concentration of 0.1 mg/ml. Thus the sterol C22-desaturase is not an attractive target for the development of antifungals | Yarrowia lipolytica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae ATCC 9763 | - |
- |
- |
Yarrowia lipolytica | - |
- |
- |
Yarrowia lipolytica UCDFST 60-26 | - |
- |
- |
[Candida] glabrata | Q56J92 | - |
- |
[Candida] glabrata NCCLS 84 | Q56J92 | - |
- |
General Information | Comment | Organism |
---|---|---|
drug target | sterol C22-desaturase is not an attractive target for the development of antifungals | [Candida] glabrata |