Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.19.41 extracted from

  • Kelly S.L, K.S.; Lamb D.C, L.D.; Baldwin B.C, B.B.; Corran A.J, C.A.; Kelly D.E, K.D.
    Characterization of Saccharomyces cerevisiae CTP61, sterol DELTA22-desaturase, and inhibition by azole antifungal agents (1997), J. Biol. Chem., 272, 9986-9988.
    View publication on PubMed
Search for more literature for 1.14.19.41

Inhibitors

Inhibitors Comment Organism Structure
fluconazole competitive inhibitor Saccharomyces cerevisiae
ketoconazole
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0204
-
 ergosta-5,7-dien-3beta-ol at pH 7.2 and 37°C Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Saccharomyces cerevisiae
-
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae DK2
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ergosta-5,7-dien-3beta-ol + NADPH + H+ + O2
-
 Saccharomyces cerevisiae ergosterol + NADP+ + H2O
-
 ?
ergosta-5,7-dien-3beta-ol + NADPH + H+ + O2
-
 Saccharomyces cerevisiae DK2 ergosterol + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CTP61
-
 Saccharomyces cerevisiae
cytochrome P-45061
-
 Saccharomyces cerevisiae
sterol DELTA22-desaturase
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000014
-
 fluconazole at pH 7.2 and 37°C Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000002
-
 at pH 7.2 and 37°C Saccharomyces cerevisiae ketoconazole
0.0000005
-
 at pH 7.2 and 37°C Saccharomyces cerevisiae fluconazole